In quantitative histology several image analysis software are avaible with good results in detecting objects both on morphometrical side (perimeter, diameter, area, shape factor) and densitometrical features (RGB or gray density). Classification usually is performed by estracting overall information y low-level features (relationships between pixels and objects) and high level features (histological textures/structures). In thi communication we ficus the possibility to exploit random effects approach in histopathological analisys (abstract only).