The importance of being (a little bit) discrete

TitleThe importance of being (a little bit) discrete
Publication TypeConference Paper
Year of Publication2009
AuthorsBortolussi L, Policriti A
EditorCannata N., Merelli E., Ulidowski I.
Conference NameSecond Workshop From Biology to Concurrency and Back (FBTC 2008)
Volume229
Pages75–92
PublisherElsevier
KeywordsBiological Modeling, Discreteness, Hybrid Systems, Robustness, Stochastic Noise
Abstract

We compare the hybrid, stochastic, and differential semantics for stochastic Concurrent Constraint Programming, focussing on the exhibited behavior of models and their robustness. By investigating in detail two case studies, a circadian clock model and the Repressilator, we comment on the effect of the introduction of a limited amount of discreteness in the description of biological systems with hybrid automata. Experimental evidence suggests that discreteness increases robustness of the models.

URLhttp://www.sciencedirect.com/science/article/pii/S1571066109000115
DOI10.1016/j.entcs.2009.02.006