Rule-Based Modelling and Simulation of Drug-Administration Policies

TitleRule-Based Modelling and Simulation of Drug-Administration Policies
Publication TypeConference Paper
Year of Publication2015
AuthorsBortolussi L, Krüger T, Wolf V
Conference NameModeling and Simulation in Medicine Symposium (MSM 2015)
PublisherCurran Associates, Inc.
Keywordsdrug design, Rule based modelling, stochastic simulation, time-inhomogeneous models

We investigate a model of drug administration in the con- text of a plaque-formation process responsible of Alzheimer’s disease. This is a polymerisation process, best described by a rule-based model to counteract the intrinsic combinatorial explosion of the underlying re- action network. Furthermore, there is the additional complicancy of time- dependent rates, modelling the effect of drugs. In the paper, we provide a novel and efficient rejection-based simulation algorithm that samples exactly the trajectory space and apply it to study the efficacy of different drug administration policies.